Restoration of Thymus Function with Bioengineered Thymus Organoids
نویسندگان
چکیده
منابع مشابه
Revisiting Thymus Function
For centuries, the thymus has been an organ in search of a function. The fact that it is a large mass of tissue in infancy was not appreciated at the beginning of the twentieth Century, as autopsies performed in infants succumbing to fatal illnesses such as diphtheria, revealed a small thymus. This resulted from stress during the illness, but the small size of the thymus was thought to be the n...
متن کاملStudies on Thymus Function
The immune functions of neonatally thymectomized C3Hf mice exposed only temporarily to thymus function show a progressive decay with time in the absence of the thymus. The immune responses studied at different ages in the range of 100-600 days were: first-set rejection of H-2-compatible and incompatible skin allografts, second-set rejection of skin allografts, capacity of spleen cells to produc...
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Concanavalin A- or phytohemagglutinin-stimulated DNA synthetic responses of 1 million normal mouse spleen cells in vitro were significantly different among various inbred strains. BALB/cJ (H-2(d)) responded better than C57BL/6J (H-2(b)) spleen cells, and the responses of C3H/HeJ or AKR/J (both H-2(k)) cells were intermediate. These responses, measured as the increment in thymidine-(3)H incorpor...
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The development of CD4(+) helper and CD8(+) cytotoxic T-cells expressing the αβ form of the T-cell receptor (αβTCR) takes place in the thymus, a primary lymphoid organ containing distinct cortical and medullary microenvironments. While the cortex represents a site of early T-cell precursor development, and the positive selection of CD4(+)8(+) thymocytes, the thymic medulla plays a key role in t...
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Irradiated and thymectomized CBA mice are markedly depressed in several immunological parameters (skin homograft rejection, graft-vs.-host activity and hemolytic plaque-forming cells of the spleen, hemolysin and hemagglutinin formation, and peripheral lymphocyte counts). In the present experiments the ability of homografts of neonatal thymus placed beneath the kidney capsule to restore immunolo...
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ژورنال
عنوان ژورنال: Current Stem Cell Reports
سال: 2016
ISSN: 2198-7866
DOI: 10.1007/s40778-016-0040-x